Order Now! - 1.866.700.0501 Home | Contact | Shipping | Returns | Our Websites | Order Status   
Creatinine Clearance Doctor's Data
  
 
Checkout   
Sign In | New Customer?
 
 Lab Tests   Vitamins  Herbs Women's Health   Men's Health     Detox   Diet & Weight loss  Energy  More »
Creatinine Clearance

Creatinine Clearance

Price: $65.00

     

Form:
By: Doctor's Data
Category: Lab Test

No Reviews Yet. Be the first to Review.
Write a Review for this Product


Free Shipping on orders over $100!
100% Secured Shopping

Accept Credit Cards

  • First morning void or 24-hour urine collection
  • Chromatography uniquely separates three precoproporphyrins and coproporphyrins I and III
  • Pre coproporphyrins reported separately and total precoproporphyrins expressed per uroporphyrins

 

Urinary porphyrins are oxidized intermediate metabolites of heme biosynthesis and have been associated with genetic disorders, metabolic disturbances/diseases, poor nutritional status, oxidative stress, and high level exposure to toxic chemicals or metals.   Specific urine porphyrin profiles are associated with high level exposure to mercury, arsenic, lead and some toxic chemicals.   Precoproporphyrins are reported separately and per unit uroporphyrin to increase detection even when heme production is very low.

 

 

Urinary porphyrins are oxidized intermediate metabolites of heme biosynthesis and are readily excreted in excess when porphyrinogens accumulate as a result of inhibition of specific enzymes in the heme biosynthetic pathway. Heme is required for oxygen binding, transport and utilization, cytochromes, and electron transport in mitrochondira.   The high rate of production of heme facilitates the use of urinary porphyrins as early and sensitive biomarkers of disorders in heme production, and has long been associated with genetic disorders, metabolic disturbances/diseases, nutritional status, oxidative stress, and high level exposure to toxic chemicals or metals.

 

Specific urinary porphyrin profiles have been associated with very high levels of toxic metals such as mercury (Hg), lead and arsenic.   Mercury specifically inhibits two enzymes in porphyrinogen metabolism: uroporphyrinogen decarboxylase and coproporphyrinogen oxidase (CPOX). Inhibition of those two enzymes, particularly in the renal cortex, results in accumulation of pentacarboxyporphyrinogen and coproporphyrinogen III.   Oxidation of the abnormally elevated porphyrinogens results in elevated urinary levels of total porphyrins, pentacarboxyporphyrin and coproporphyrin III. Recent research has identified an additional abnormal porphyrin in the urine of Hg-exposed dentists and also in rats fed very high levels of mercury for extended periods of time. A third Hg-associated porphyrin is most commonly referred to as “precoproporphyrin” as it elutes after pentacarboxyporphyrin and before coproporphyrin I. The recently described precoproporphyrin has yet to be characterized with respect to molecular identity and appears to be elevated in Hg exposed individuals who carry a variant of the CPOX gene (CPOX4 polymorphism). Research at Doctor’s Data, Inc. has identified three separate precoproporphyrin peaks.   Since knowledge about the Hg-associated precoproporphyrin entities is limited, we report the levels of all three peaks separately, as well as the total, for research use.   Since uroporphyrin levels are not known to be affected by Hg, we also report the total precoproporphyrins-to-uroporphyrin ratio to increase the sensitivity for detecting abnormalities in individuals with low heme biosynthesis as may occur in children with nutritional deficiencies and/or autism.

 

Arsenic exposure has been associated with elevated levels of uroporphyrins and coproporphyrin I, and an elevated ratio of coproporphyrins (I: III). Lead exposure has been associated with elevated levels of coproporphyrin III.

 

Exposure to hexachlorobenzene and dioxin has been associated with elevated levels of uroporphyrins. Exposure to polyvinylchloride (PVC) and polybrominated biphenyl has been associated with elevated levels of coproporphyrins.

 

Various drugs and other substances can suppress enzymes involved in porphyrin metabolism and affect the levels of urinary porphyrins. Such compounds include alcohol, sedatives, analgesics, antibiotics, estrogens, and oral contraceptives. Anemia, pregnancy, and liver disease can also affect porphyrin metabolism.

 

The Urine Porphyrins test is best used in conjunction with urine toxic metals pre- and post-provocation testing.



Creatinine Clearance

Price: $65.00       

Free Shipping on orders over $100!
100% Secured Shopping


Shop by Brand:
Shop by Category:
Browse by Brand
Browse by Category
Browse Alphabetically
Browse New Products
Browse Sale Products
Browse Featured


CP-1 (Comprehensive Parasitology x 1 sample ) CP-1 (Comprehensive Parasitology x 1 sample )
by Doctor's Data

$199.00
CP-2 (Comprehensive Parasitology x 2 samples) CP-2 (Comprehensive Parasitology x 2 samples)
by Doctor's Data

$234.00
CSAP-2 (Comprehensive Stool Analysis and Parasitology x 2) CSAP-2 (Comprehensive Stool Analysis and Parasitology x 2)
by Doctor's Data

$395.00
Hair Elements Hair Elements
by Doctor's Data

$125.00
Hair Toxic Element Exposure Profile Hair Toxic Element Exposure Profile
by Doctor's Data

$125.00

Home | Contact | Shipping | Returns | Privacy Policy | Order Status | Product Index | Our Websites
  Copyright 2015 eVital Health | All Rights Reserved   
BizRate Customer Certified (GOLD) Site - eVital Health Reviews at Bizrate
Accept Credit Cards
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. The products and the claims made about specific products on or through this site have not been evaluated by the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. Information about each product is taken from the labels of the products or from the manufacturer's advertising material. we are not responsible for any statements or claims that various manufacturers make about their products. We cannot be held responsible for typographical errors or product formulation changes.