•Decreases Pro-inflammatory cytokines
•Normalizes cytokine-induced neurotransmitter imbalances
•Supports acetylcholine levels
•Improves mood, sleep quality, memory, and mental clarity
Changes in mood and mental health are frequently associated with pro-inflammatory cytokines that trigger imbalances in certain neurotransmitters. Avipaxin supports normal brain function by utilizing
acetylcholine and the cholinergic anti-inflammatory pathway to decrease elevated pro-inflammatory cytokine levels.
Avipaxin contains Huperzine A, which is a potent inhibitor of
acetylcholinesterase, the enzyme that metabolizes acetylcholine.
Blocking acetylcholinesterase increases circulating levels of
acetylcholine. Avipaxin also contains α-Glyceryl Phosphoryl Choline
(α-GPC) and Acetyl-L-Carnitine. These ingredients supply choline
and acetyl groups, respectively, for acetylcholine synthesis.
Recently, research1 on the role of the role of the vagus nerve in mediating immune activation has been done and it has been found that cytokines released upon immune challenge activate the vagal nerve that result in increased cortisol levels via the Hypothalmic-Pituitary-Adrenal axis2. Vagal pathways from the brain secrete acetylcholine, which binds to activated immune cells and down-regulates those cells’ pro-inflammatory cytokine production3. Avipaxin supports acetylcholine levels, leading to a down-regulation of pro-inflammatory cytokines and a subsequent normalization of neurotransmitter concentrations4.
1. Pavlov V, Tracey K et al., Molecular Medicine 9:125-134 (2003); Figure 1.
2. Tracey K. Nat Rev Immunol 2009;9:418-428.
3. Tracey K. J Clin Invest 2007;117:289-296.
4. Thayer J, Fischer J. J Intern Med 2009;265:439-447.
Available in a 60 ct capsule.